(19)

(11)

EP 0 573 599 A1

(12)

(43) Date of publication: 15.12.1993 Bulletin 1993/50 (21) Application number: 92908432.0 (22) Date of filing: 24.02.1992

(51) International Patent Classification (IPC):  C07K 14/ 575( . ) C07K 1/ 30( . ) C30B 7/ 00( . ) C30B 29/ 58( . ) C07K 1/ 14( . ) C07K 14/ 62( . ) C30B 7/ 08( . ) C30B 30/ 08( . ) (86) International application number: PCT/US1992/001125 (87) International publication number: WO 1992/014869 (03.09.1992 Gazette 1992/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 25.02.1991 US 19910659948 18.02.1992 US 19920836658 (71) Applicants: SCHERING CORPORATION Kenilworth New Jersey 07033 (US) THE UAB RESEARCH FOUNDATION Birmingham, AL 35209-2010 (US)	(72) Inventors: BUGG, Charles, E. Birmingham, AL 35200 (US) DE LUCAS, Lawrence, J. Birmingham, AL 35200 (US) NAGABHUSHAN, Tattanahalli, L. Parsippany, NJ 07054 (US) TROTTA, Paul, P. Secaucus, NJ 07094 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)