(19)
(11) EP 0 573 617 A1

(12)

(43) Date of publication:
15.12.1993 Bulletin 1993/50

(21) Application number: 92915059.0

(22) Date of filing: 22.05.1992
(51) International Patent Classification (IPC): 
C07D 473/ 04( . )
A61K 31/ 52( . )
A61P 35/ 00( . )
A61K 31/ 47( . )
A61K 31/ 522( . )
(86) International application number:
PCT/US1992/004349
(87) International publication number:
WO 1992/021344 (10.12.1992 Gazette 1992/31)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30) Priority: 24.05.1991 US 19910704992
16.07.1991 US 19910732227

(60) Divisional application:
01125488.5 / 

(60) Divisional application:
01126058.5 / 1214938

(71) Applicant: Fred Hutchinson Cancer Research Center
Seattle Washington 98104 (US)

(72) Inventors:
  • BIANCO, James A.
    Seattle, WA 98116 (US)
  • BURSTEN, Stuart L.
    Snoqualmie, WA 98065 (US)
  • SINGER, Jack W.
    Seattle, WA 98122 (US)

(74) Representative: Goldin, Douglas Michael, et al 
J.A. KEMP & CO. 14, South Square Gray's Inn
London WC1R 5LX
London WC1R 5LX (GB)

   


(54) MODULATION OF CELLULAR RESPONSE TO EXTERNAL STIMULI