(19)

(11)

EP 0 574 477 A1

(12)

(43) Date of publication: 22.12.1993 Bulletin 1993/51 (21) Application number: 92906079.0 (22) Date of filing: 04.03.1992

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61K 31/ 47( . ) A61K 31/ 445( . ) (86) International application number: PCT/EP1992/000492 (87) International publication number: WO 1992/015304 (17.09.1992 Gazette 1992/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 05.03.1991 GB 19910004656 (71) Applicant: SMITHKLINE BEECHAM FARMACEUTICI S.p.A. I-20021 Baranzate di Bollate (MI) (IT)	(72) Inventors: GIARDINA, Giuseppe Dr Lo Zambeletti S.p.A. I-20021 Baranzate (IT) CLARKE, Geoffrey Douglas Dr Lo Zambeletti S.p.A. I-20021 Baranzate (IT) (74) Representative: Russell, Brian John  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)