ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY - Patent 0575339

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EP 0 575 339 A1

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(43)	Date of publication:
	29.12.1993 Bulletin 1993/52

(21)	Application number: 92902895.0

(22)	Date of filing: 17.12.1991

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International Patent Classification (IPC):

A61K 38/ 22^{( . )}
C07K 14/ 00^{( . )}
C12N 15/ 09^{( . )}
A61K 38/ 00^{( . )}

A61P 43/ 00^{( . )}
C07K 14/ 50^{( . )}
C12P 21/ 02^{( . )}
C12R 1/ 19^{( . )}

(86)	International application number:
	PCT/US1991/009441

(87)	International publication number:
	WO 1992/011360 (09.07.1992 Gazette 1992/17)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

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Priority:

18.12.1990 US 19900632456

(71)	Applicant: AMGEN INC.
	Thousand Oaks California 91320 -1789 (US)

(72)	Inventors:
	ARAKAWA, Tsutomu Thousand Oaks, CA 91360 (US) FOX, Gary, Michael Newbury Park, CA 91320 (US)

(74)	Representative: Brown, John David, et al
	FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)

(54)	ANALOGS OF ACIDIC FIBROBLAST GROWTH FACTOR HAVING ENHANCED STABILITY AND BIOLOGICAL ACTIVITY