ANTIVIRAL ACTIVITY AND RESOLUTION OF 2-HYDROXYMETHYL-5-(5-FLUOROCYTOSIN-1-YL)-1,3-OXATHIOLANE

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EP 0 575 482 A1

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(43)	Date of publication:
	29.12.1993 Bulletin 1993/52

(21)	Application number: 92908027.0

(22)	Date of filing: 20.02.1992

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International Patent Classification (IPC):

A61K^{( . )}
A61K 31/ 505^{( . )}
A61K 31/ 513^{( . )}
A61P 31/ 12^{( . )}
A61P 37/ 04^{( . )}
C07D 327/ 04^{( . )}
C07D 411/ 04^{( . )}
C07H 19/ 10^{( . )}
C12P 17/ 16^{( . )}
C12P 41/ 00^{( . )}

C07D^{( . )}
A61K 31/ 39^{( . )}
A61P 1/ 16^{( . )}
A61P 31/ 18^{( . )}
C07D 239/ 36^{( . )}
C07D 405/ 04^{( . )}
C07H 19/ 06^{( . )}
C12P 13/ 00^{( . )}
C12P 19/ 38^{( . )}

(86)	International application number:
	PCT/US1992/001339

(87)	International publication number:
	WO 1992/014743 (03.09.1992 Gazette 1992/23)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

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Priority:

22.02.1991 US 19910659760
26.07.1991 US 19910736089
12.02.1992 US 19920831153

(60)	Divisional application:
	04076245.2 / 1439177

(60)	Divisional application:
	10163846.8 /

(60)	Divisional application:
	99203367.0 / 0984013

(71)	Applicant: EMORY UNIVERSITY
	Atlanta, GA 30322 (US)

(72)	Inventors:
	LIOTTA, Dennis, C. Stone Mountain, GA 30088 (US) SCHINAZI, Raymond, F. Decatur, GA 30333 (US) CHOI, Woo-Baeg North Brunswick, NJ 08902 (US)

(74)	Representative: Bassett, Richard Simon
	ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)

(54)	ANTIVIRAL ACTIVITY AND RESOLUTION OF 2-HYDROXYMETHYL-5-(5-FLUOROCYTOSIN-1-YL)-1,3-OXATHIOLANE