(19)

(11)

EP 0 575 544 A1

(12)

(43) Date of publication: 29.12.1993 Bulletin 1993/52 (21) Application number: 92909302.0 (22) Date of filing: 19.03.1992

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61K 39/ 275( . ) A61K 39/ 295( . ) A61P 31/ 12( . ) C12N 7/ 00( . ) C12N 15/ 09( . ) C12N 15/ 86( . ) A61K 39/ 015( . ) A61K 39/ 285( . ) A61P 31/ 04( . ) C07K 14/ 445( . ) C12N 7/ 01( . ) C12N 15/ 30( . ) C12N 15/ 863( . ) (86) International application number: PCT/US1992/002207 (87) International publication number: WO 1992/016616 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 20.03.1991 US 19910672183 18.03.1992 US 19920852305 (71) Applicant: VIROGENETICS CORPORATION Troy, NY 12180 (US)	(72) Inventors: PAOLETTI, Enzo Delmar, NY 12054 (US) DE TAISNE, Charles F-69005 Lyon (FR) TINE, John, A. Scotia, NY 12302 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)