(19)

(11)

EP 0 575 556 A1

(12)

(43) Date of publication: 29.12.1993 Bulletin 1993/52 (21) Application number: 92910620.0 (22) Date of filing: 10.03.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 39/ 395( . ) A61P 43/ 00( . ) C07H 7/ 06( . ) A61K 38/ 46( . ) A61K 47/ 48( . ) C07D 519/ 00( . ) (86) International application number: PCT/US1992/001958 (87) International publication number: WO 1992/016203 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 15.03.1991 US 19910669745 (71) Applicant: HAWAII BIOTECHNOLOGY GROUP, INC. Aiea, HI 96701 (US)	(72) Inventors: BIGNAMI, Gary S. Waialua, HI 96791 (US) GROTHAUS, Paul G. Mililani, HI 96789 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)