(19)

(11)

EP 0 575 614 A1

(12)

(43) Date of publication: 29.12.1993 Bulletin 1993/52 (21) Application number: 92905746.0 (22) Date of filing: 09.03.1992

(51) International Patent Classification (IPC):  A61K 31/ 425( . ) A61K 31/ 44( . ) A61P 43/ 00( . ) C07D 277/ 48( . ) C07D 417/ 14( . ) A61K 31/ 426( . ) A61P 31/ 04( . ) C07D 277/ 20( . ) C07D 417/ 04( . ) (86) International application number: PCT/JP1992/000279 (87) International publication number: WO 1992/016526 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 13.03.1991 US 19910668915 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP)	(72) Inventors: TAKASUGI, Hisashi Sakai-shi Osaka 591 (JP) KATSURA, Yousuke Toyonaka-shi Osaka 560 (JP) INOUE, Yoshikazu Amagasaki-shi Hyogo 661 (JP) TOMISHI, Tetsuo Minoo-shi Osaka 562 (JP) (74) Representative: Türk, Dietmar, Dr. rer. nat., et al  Türk, Gille, Hrabal, Leifert Patentanwälte Brucknerstrasse 20 D-40593 Düsseldorf D-40593 Düsseldorf (DE)