HYDRAZINE CONTAINING CONJUGATES OF POLYPEPTIDES AND GLYCOPOLYPEPTIDES WITH POLYMERS - Patent 0576589

(19)

(11)

EP 0 576 589 A1

(12)

(43)	Date of publication:
	05.01.1994 Bulletin 1994/01

(21)	Application number: 92909326.0

(22)	Date of filing: 12.03.1992

(51)

International Patent Classification (IPC):

A61K 38/ 00^{( . )}
A61K 38/ 43^{( . )}
C07K 1/ 113^{( . )}
C07K 14/ 00^{( . )}
C07K 14/ 505^{( . )}
C07K 14/ 53^{( . )}
C07K 14/ 555^{( . )}
C07K 14/ 61^{( . )}
C07K 14/ 65^{( . )}
C07K 14/ 745^{( . )}
C07K 14/ 76^{( . )}
C07K 17/ 08^{( . )}
C08F 8/ 30^{( . )}
C08G 69/ 10^{( . )}
C08L 101/ 00^{( . )}
C12N 9/ 14^{( . )}

A61K 38/ 22^{( . )}
A61K 47/ 48^{( . )}
C07K 7/ 16^{( . )}
C07K 14/ 42^{( . )}
C07K 14/ 52^{( . )}
C07K 14/ 54^{( . )}
C07K 14/ 575^{( . )}
C07K 14/ 62^{( . )}
C07K 14/ 655^{( . )}
C07K 14/ 755^{( . )}
C07K 16/ 00^{( . )}
C07K 17/ 10^{( . )}
C08G 65/ 32^{( . )}
C08G 81/ 00^{( . )}
C12N 9/ 02^{( . )}
C12N 9/ 76^{( . )}

(86)	International application number:
	PCT/US1992/002047

(87)	International publication number:
	WO 1992/016555 (01.10.1992 Gazette 1992/25)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30)

Priority:

18.03.1991 US 19910672696

(71)	Applicant: ENZON, INC.
	Piscataway, NJ 08854-3998 (US)

(72)	Inventors:
	ZALIPSKY, Samuel Princeton, NJ 08540 (US) LEE, Chyi Princeton Junction, NJ 08850 (US) MENON-RUDOLPH, Sunitha Highland Park, NJ 08904 (US)

(74)	Representative: Smulders, Theodorus A.H.J., Ir., et al
	Vereenigde Octrooibureaux Nieuwe Parklaan 97 NL-2587 BN 's-Gravenhage NL-2587 BN 's-Gravenhage (NL)

(54)	HYDRAZINE CONTAINING CONJUGATES OF POLYPEPTIDES AND GLYCOPOLYPEPTIDES WITH POLYMERS