(19)

(11)

EP 0 576 609 A1

(12)

(43) Date of publication: 05.01.1994 Bulletin 1994/01 (21) Application number: 92910489.0 (22) Date of filing: 13.03.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12P 21/ 08( . ) G01N 33/ 566( . ) A61K 39/ 395( . ) A61P 43/ 00( . ) C07K 14/ 705( . ) C07K 16/ 28( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1992/002091 (87) International publication number: WO 1992/016623 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 15.03.1991 US 19910670603 03.10.1991 US 19910771332 (71) Applicants: BERLEX LABORATORIES, INC. Cedar Knolls, NJ 07927-2094 (US) THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services Bethesda, Maryland 20892 (US)

(72) Inventors: BATTEY, James, F., Jr. Bethesda, MD 20817 (US) CORJAY, Martha, H. Wilmington, DE 19808 (US) FATHI, Zahra Silver Springs, MD 20904 (US) FELDMAN, Richard, I. El Cerrito, CA 94530 (US) HARKIN, Richard, N. Alameda, CA 94501 (US) SLATTERY, Timothy, K. Mountain View, CA 94403 (US) WADA, Etsuko Rockville, MD 20852 (US) WU, James, M. El Cerrito, CA 94530 (US) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co. 15, Hamilton Square Birkenhead Merseyside L41 6BR Birkenhead Merseyside L41 6BR (GB)