(19)

(11)

EP 0 577 612 A1

(12)

(43) Date of publication: 12.01.1994 Bulletin 1994/02 (21) Application number: 92904825.0 (22) Date of filing: 18.02.1992

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) (86) International application number: PCT/EP1992/000338 (87) International publication number: WO 1992/014491 (03.09.1992 Gazette 1992/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 26.02.1991 IT 1991MI00491 (71) Applicant: ITALFARMACO S.p.A. I-20126 Milan (IT)	(72) Inventors: PORRO, Giuliana I-20126 Milano (IT) MODENA, Daniela I-20126 Milano (IT) STIRPE, Fiorenzo I-20126 Milano (IT) GROMO, Gianni I-20126 Milano (IT) (74) Representative: Bianchetti, Giuseppe  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milan I-20122 Milan (IT)