(19)

(11)

EP 0 578 633 A1

(12)

(43) Date of publication: 19.01.1994 Bulletin 1994/03 (21) Application number: 91907079.0 (22) Date of filing: 25.03.1991

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) A61P 29/ 00( . ) A61K 31/ 519( . ) C07D 475/ 08( . ) (86) International application number: PCT/US1991/001999 (87) International publication number: WO 1991/014433 (03.10.1991 Gazette 1991/23)

(84) Designated Contracting States: CH DE GB LI (30) Priority: 29.03.1990 US 19900500911 (71) Applicant: NAIR, Madhavan G. Mobile, AL 36695 (US)	(72) Inventors: NAIR, Madhavan, G. Mobile, AL 36695 (US) ALARCON, Graciela Birmingham, AL 35226 (US) CASTANEDA, Oswaldo Lima (PE) KOOPMAN, William, J. Helena, AL 35080 (US) KRUMDIECK, Carlos, L. Birmingham, AL 35226 (US) (74) Representative: Lord, Hilton David  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)