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EP 0 578 790 A1

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(43) Date of publication: 19.01.1994 Bulletin 1994/03 (21) Application number: 92923074.0 (22) Date of filing: 12.11.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 48/ 00( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 38/ 46( . ) A61P 43/ 00( . ) C12N 9/ 24( . ) C12N 15/ 56( . ) (86) International application number: PCT/AU1992/000611 (87) International publication number: WO 1993/010244 (27.05.1993 Gazette 1993/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 14.11.1991 AU 19900000094 (71) Applicant: WOMEN'S AND CHILDREN'S HOSPITAL North Adelaide, S.A. 5006 (AU)

(72) Inventors: SCOTT, Hamish, Steel Millswood, S.A. 5034 (AU) ANSON, Donald, Stewart Thebarton, S.A. 5031 (AU) ORSBORN, Annette, Marie Hallett Cove, S.A. 5158 (AU) NELSON, Paul, Victor Colonel Light Gardens, S.A. 5041 (AU) CLEMENTS, Peter, Roy West Lakes, S.A. 5021 (AU) MORRIS, Charles, Phillip Unley, S.A. 5061 (AU) HOPWOOD, John, Joseph Stonyfell, S.A. 5066 (AU) (74) Representative: Dzieglewska, Hanna Eva  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)