(19)

(11)

EP 0 579 643 A1

(12)

(43) Date of publication: 26.01.1994 Bulletin 1994/04 (21) Application number: 92907588.0 (22) Date of filing: 02.04.1992

(51) International Patent Classification (IPC):  C07H( . ) A61K 31/ 7042( . ) A61K 31/ 7076( . ) A61P 7/ 02( . ) C07F 9/ 38( . ) C07H 19/ 207( . ) A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 31/ 708( . ) C07D 473/ 00( . ) C07H 19/ 20( . ) (86) International application number: PCT/GB1992/000590 (87) International publication number: WO 1992/017488 (15.10.1992 Gazette 1992/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 06.04.1991 GB 19910007236 07.11.1991 GB 19910023671 (71) Applicant: FISONS plc Ipswich Suffolk IP1 1QH (GB)	(72) Inventors: INGALL, Anthony Howard Loughborough, Leicestershire LE11 3NW (GB) CAGE, Peter Alan Shepshed, Leicestershire LE12 9BZ (GB) (74) Representative: Wright, Robert Gordon McRae  FISONS plc 12 Derby Road Loughborough Leicestershire LE11 0BB Loughborough Leicestershire LE11 0BB (GB)