(19)
(11) EP 0 579 648 A1

(12)

(43) Date of publication:
26.01.1994 Bulletin 1994/04

(21) Application number: 92907683.0

(22) Date of filing: 06.04.1992
(51) International Patent Classification (IPC): 
A61K 31/ 16( . )
A61K 31/ 22( . )
A61P 43/ 00( . )
C07C 327/ 32( . )
A61K 31/ 19( . )
A61P 29/ 00( . )
C07C 323/ 60( . )
C07D 295/ 18( . )
(86) International application number:
PCT/GB1992/000612
(87) International publication number:
WO 1992/017444 (15.10.1992 Gazette 1992/26)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 08.04.1991 GB 19910007367

(71) Applicant: SMITHKLINE BEECHAM P.L.C.
Brentford, Middlesex TW8 9EP (GB)

(72) Inventors:
  • MARKWELL, Roger, Edward
    The Pinnacles Harlow Essex CM19 5AD (GB)
  • WARD, Robert, William
    The Pinnacles Harlow Essex CM19 5AD (GB)
  • RATCLIFFE, Steven, John
    The Pinnacles Harlow Essex CM19 5AD (GB)

(74) Representative: Florence, Julia Anne, et al 
SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road
Brentford, Middlesex TW8 9BD
Brentford, Middlesex TW8 9BD (GB)

   


(54) THIOL-CARBOXYLIC ACID DERIVATIVES AS COLLAGENASE INHIBITORS