(19)

(11)

EP 0 579 650 A1

(12)

(43) Date of publication: 26.01.1994 Bulletin 1994/04 (21) Application number: 92907701.0 (22) Date of filing: 06.04.1992

(51) International Patent Classification (IPC):  A61K 31/ 395( . ) C07D 245/ 02( . ) A61P 3/ 00( . ) (86) International application number: PCT/GB1992/000611 (87) International publication number: WO 1992/017460 (15.10.1992 Gazette 1992/26)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 08.04.1991 GB 19910007368 (71) Applicant: SMITHKLINE BEECHAM P.L.C. Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: MARKWELL, Roger, Edward SmithKline Beecham Harlow Essex CM19 5AD (GB) WARD, Robert, William SmithKline Beecham Harlow Essex CM19 5AD (GB) RAHMAN, Shahzad, Sharooq SmithKline Beecham Harlow Essex CM19 5AD (GB) (74) Representative: Florence, Julia Anne, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)