(19)

(11)

EP 0 579 695 A1

(12)

(43) Date of publication: 26.01.1994 Bulletin 1994/04 (21) Application number: 92908626.0 (22) Date of filing: 12.03.1992

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) A61P 37/ 04( . ) C07D 215/ 48( . ) C07D 405/ 06( . ) A61P 31/ 12( . ) C07D 215/ 38( . ) C07D 241/ 44( . ) (86) International application number: PCT/US1992/001746 (87) International publication number: WO 1992/016508 (01.10.1992 Gazette 1992/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 14.03.1991 US 19910669082 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)

(72) Inventors: ARISTOFF, Paul, Adrian Portage, MI 49002 (US) BANNISTER, Brian Kalamazoo, MI 49008 (US) BILES, Carolyn Climax, MI 490034 (US) MARTIN, David, Glenn Kalamazoo, MI 49001 (US) ROMERO, Donna, Lee Kalamazoo, MI 49008 (US) SKULNICK, Harvey, Irving Kalamazoo, MI 49009 (US) SMITH, Herman, Walden Kalamazoo, MI 49007 (US) ALTHAUS, Irene, Wilson Portage, MI 49002 (US) REUSSER, Fritz Portage, MI 49002 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)