(19)
(11) EP 0 579 747 A1

(12)

(43) Date of publication:
26.01.1994 Bulletin 1994/04

(21) Application number: 92910543.0

(22) Date of filing: 20.03.1992
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
C07K 14/ 74( . )
A61P 37/ 00( . )
(86) International application number:
PCT/US1992/002419
(87) International publication number:
WO 1992/016234 (01.10.1992 Gazette 1992/25)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30) Priority: 22.03.1991 US 19910673634

(71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Philadelphia, Pennsylvania 19104-3147 (US)

(72) Inventors:
  • WILLIAMS, William, V.
    Havertown, PA 19083 (US)
  • RUBIN, Donald, H.
    Wynnewood, PA 19096 (US)
  • WEINER, David, B.
    Wynnewood, PA 19096 (US)
  • GREENE, Mark, I.
    Penn Valley, PA 95946 (US)

(74) Representative: Stebbing, Peter John Hunter, et al 
Ablett & Stebbing 45 Lancaster Mews Lancaster Gate
London W2 3QQ
London W2 3QQ (GB)

   


(54) METHOD OF MODULATING MAMMALIAN T-CELL RESPONSE