(19)

(11)

EP 0 580 812 A1

(12)

(43) Date of publication: 02.02.1994 Bulletin 1994/05 (21) Application number: 92917468.0 (22) Date of filing: 09.04.1992

(51) International Patent Classification (IPC):  C07D( . ) A61P 17/ 00( . ) C07D 498/ 22( . ) A61K 31/ 55( . ) A61P 35/ 00( . ) C07H 19/ 044( . ) (86) International application number: PCT/US1992/002661 (87) International publication number: WO 1992/018507 (29.10.1992 Gazette 1992/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 11.04.1991 US 19910683770 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: McCOMBIE, Stuart, W. Caldwell, NJ 07006 (US) SHANKAR, Bandarpalle, B. Somerville, NJ 08876 (US) KIRKUP, Michael, P. Bridgewater, NJ 08807 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)