(19)

(11)

EP 0 584 212 A1

(12)

(43) Date of publication: 02.03.1994 Bulletin 1994/09 (21) Application number: 92911814.0 (22) Date of filing: 13.05.1992

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61K 39/ 104( . ) A61K 9/ 127( . ) A61K 39/ 39( . ) (86) International application number: PCT/US1992/004055 (87) International publication number: WO 1992/020370 (26.11.1992 Gazette 1992/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 13.05.1991 US 19910699144 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Berkeley, California 94704-1318 (US)	(72) Inventors: ABRAHAM, Edward Los Angeles, CA 90048 (US) CHANG, Yi-Han Los Angeles, CA 90077 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)