(19)

(11)

EP 0 584 250 A1

(12)

(43) Date of publication: 02.03.1994 Bulletin 1994/09 (21) Application number: 92912707.0 (22) Date of filing: 14.05.1992

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 4164( . ) A61K 31/ 44( . ) A61K 31/ 554( . ) A61P 43/ 00( . ) C07D 233/ 64( . ) C07D 233/ 70( . ) C07D 403/ 10( . ) A61K 31/ 415( . ) A61K 31/ 4178( . ) A61K 31/ 55( . ) A61P 5/ 42( . ) C07D 233/ 60( . ) C07D 233/ 68( . ) C07D 233/ 90( . ) (86) International application number: PCT/US1992/003873 (87) International publication number: WO 1992/020342 (26.11.1992 Gazette 1992/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 15.05.1991 US 19910700740 (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY Wilmington Delaware 19898 (US)	(72) Inventor: WONG, Pancras, Chor, Bun Wilmington, DE 19808 (US) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) D-50667 Köln D-50667 Köln (DE)