(19)

(11)

EP 0 584 339 A1

(12)

(43) Date of publication: 02.03.1994 Bulletin 1994/09 (21) Application number: 93907102.0 (22) Date of filing: 03.03.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 35/ 34( . ) A61K 48/ 00( . ) C12N 5/ 10( . ) A61K 31/ 70( . ) A61K 38/ 00( . ) C12N 5/ 077( . ) C12P 21/ 00( . ) (86) International application number: PCT/US1993/001815 (87) International publication number: WO 1993/017697 (16.09.1993 Gazette 1993/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.03.1992 US 19920846186 (71) Applicants: WOLFF, Jon A. Madison, WI 53705 (US) JIAO, Shou Shu Madison, WI 53705 (US)	(72) Inventors: WOLFF, Jon A. Madison, WI 53705 (US) JIAO, Shou Shu Madison, WI 53705 (US) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)