(19)

(11)

EP 0 585 383 A1

(12)

(43) Date of publication: 09.03.1994 Bulletin 1994/10 (21) Application number: 92913103.0 (22) Date of filing: 14.05.1992

(51) International Patent Classification (IPC):  A61K 31/ 415( . ) A61K 31/ 4433( . ) A61P 9/ 12( . ) A61P 15/ 00( . ) C07D 409/ 14( . ) A61K 31/ 44( . ) A61P 9/ 00( . ) A61P 13/ 02( . ) A61P 27/ 02( . ) (86) International application number: PCT/US1992/004071 (87) International publication number: WO 1992/020651 (26.11.1992 Gazette 1992/29)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 15.05.1991 GB 19910105320 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406 (US)	(72) Inventors: GIRARD, Gerald, Robert Bensalem, PA 19020 (US) HILL, David, Taylor North Wales, PA 19454 (US) WEINSTOCK, Joseph Phoenixville, PA 19406 (US) (74) Representative: Thompson, Clive Beresford, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)