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EP 0 586 537 A1

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(43) Date of publication: 16.03.1994 Bulletin 1994/11 (21) Application number: 92912475.0 (22) Date of filing: 01.05.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 1/ 02( . ) A61P 7/ 02( . ) A61P 13/ 02( . ) A61P 27/ 02( . ) A61P 35/ 02( . ) C07K 5/ 02( . ) C07K 14/ 81( . ) A61K 38/ 55( . ) A61P 3/ 00( . ) A61P 9/ 10( . ) A61P 15/ 00( . ) A61P 29/ 00( . ) A61P 43/ 00( . ) C07K 5/ 06( . ) (86) International application number: PCT/US1992/003809 (87) International publication number: WO 1992/021360 (10.12.1992 Gazette 1992/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 28.05.1991 US 19910705826 24.04.1992 US 19920873905 (71) Applicant: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)

(72) Inventors: SAHOO, Soumya, P. Old Bridge, NJ 08857 (US) POLO, Scott, A. Yardley, PA 19067 (US) DURETTE, Philippe, L. New Providence, NJ 07974 (US) ESSER, Craig, K. Keasbey, NJ 08832 (US) HAGMANN, William, K. Westfield, NJ 07090 (US) KOPKA, Ihor, E. Millburn, NJ 07041 (US) CHAPMAN, Kevin, T. Scotch Plains, NJ 07076 (US) CALDWELL, Charles, G. Scotch Plains, NJ 07076 (US) (74) Representative: Thompson, John Dr., et al  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)