(19)

(11)

EP 0 586 632 A1

(12)

(43) Date of publication: 16.03.1994 Bulletin 1994/11 (21) Application number: 93903968.0 (22) Date of filing: 13.02.1993

(51) International Patent Classification (IPC):  A61K 31/ 55( . ) C07D 403/ 04( . ) A61P 31/ 12( . ) (86) International application number: PCT/EP1993/000352 (87) International publication number: WO 1993/017010 (02.09.1993 Gazette 1993/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.02.1992 US 19920841672 (71) Applicant: F. HOFFMANN-LA ROCHE AG CH-4002 Basel (CH)	(72) Inventors: HSU, Ming-Chu New York, NY 10028 (US) HURYN, Donna, Mary Allentown, NJ 08501 (US) TAM, Steve, Yik-Kai West Caldwell, NJ 07006 (US) (74) Representative: Mahé, Jean, et al  Postfach 3255 Grenzacherstrasse 124 CH-4002 Basel CH-4002 Basel (CH)