(19)

(11)

EP 0 587 590 A1

(12)

(43) Date of publication: 23.03.1994 Bulletin 1994/12 (21) Application number: 92909695.0 (22) Date of filing: 07.05.1992

(51) International Patent Classification (IPC):  A61K 38/ 22( . ) A61P 31/ 12( . ) A61K 38/ 18( . ) (86) International application number: PCT/EP1992/000998 (87) International publication number: WO 1992/021362 (10.12.1992 Gazette 1992/31)

(84) Designated Contracting States: DE GB IT (30) Priority: 03.06.1991 GB 19910118851 (71) Applicant: FARMITALIA CARLO ERBA S.r.l. I-20159 Milano (IT)	(72) Inventors: UNGHERI, Domenico I-20015 Parabiago (IT) CARMINATI, Paolo I-20131 MIlan (IT) MAZUE', Guy I-20148 Milan (IT) RONCUCCI, Romeo I-20159 Milan (IT) (74) Representative: Ferrario, Vittorino  Pharmacia S.p.A. Patent Department Via Bisceglie, 104 I-20152 Milano I-20152 Milano (IT)