(19)

(11)

EP 0 587 756 A1

(12)

(43) Date of publication: 23.03.1994 Bulletin 1994/12 (21) Application number: 92913385.0 (22) Date of filing: 26.05.1992

(51) International Patent Classification (IPC):  A61K 31/ 18( . ) A61K 31/ 4427( . ) A61K 31/ 445( . ) C07C 311/ 02( . ) C07D 211/ 60( . ) C07D 401/ 12( . ) A61K 31/ 40( . ) A61K 31/ 4433( . ) A61P 37/ 06( . ) C07D 207/ 48( . ) C07D 211/ 96( . ) C07D 409/ 12( . ) (86) International application number: PCT/US1992/004391 (87) International publication number: WO 1992/021313 (10.12.1992 Gazette 1992/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 24.05.1991 US 19910705371 (71) Applicant: VERTEX PHARMACEUTICALS INCORPORATED Cambridge, MA 02139-4211 (US)	(72) Inventor: DUFFY, John P. Somerville, MA 02143 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)