(19)

(11)

EP 0 587 780 A1

(12)

(43) Date of publication: 23.03.1994 Bulletin 1994/12 (21) Application number: 92913710.0 (22) Date of filing: 05.06.1992

(51) International Patent Classification (IPC):  A61K 39/ 12( . ) A61K 39/ 395( . ) A61P 31/ 12( . ) C07H 21/ 00( . ) C07K 14/ 435( . ) C07K 16/ 10( . ) C12N 7/ 01( . ) C12N 15/ 50( . ) C12P 21/ 00( . ) C12Q 1/ 68( . ) G01N 33/ 53( . ) A61K 39/ 00( . ) A61K 39/ 215( . ) A61K 39/ 42( . ) A61P 31/ 14( . ) C07K 14/ 08( . ) C07K 16/ 00( . ) C12N 7/ 00( . ) C12N 15/ 09( . ) C12N 15/ 66( . ) C12P 21/ 02( . ) C12Q 1/ 70( . ) G01N 33/ 569( . ) (86) International application number: PCT/NL1992/000096 (87) International publication number: WO 1992/021375 (10.12.1992 Gazette 1992/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 06.06.1991 EP 19910201398 18.03.1992 EP 19920200781 (71) Applicant: STICHTING CENTRAAL DIERGENEESKUNDIG INSTITUUT NL-8219 PH Lelystad (NL)

(72) Inventors: WENSVOORT, Gert NL-7971 CP Havelte (NL) TERPSTRA, Catharinus NL-8242 CC Lelystad (NL) POL, Joannes, Maria, Anthonis NL-8243 HA Lelystad (NL) MOORMANN, Robertus, Jocobus, Maria NL-8252 EH Dronten (NL) MEULENBERG, Johanna, Jacoba, Maria NL-1053 XP Amsterdam (NL) (74) Representative: Smulders, Theodorus A.H.J., Ir., et al  Vereenigde Octrooibureaux Nieuwe Parklaan 97 NL-2587 BN 's-Gravenhage NL-2587 BN 's-Gravenhage (NL)