(19)
(11) EP 0 587 806 A1

(12)

(43) Date of publication:
23.03.1994 Bulletin 1994/12

(21) Application number: 92914704.0

(22) Date of filing: 20.05.1992
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
A61K 39/ 395( . )
A61P 15/ 00( . )
A61P 37/ 00( . )
C07K 14/ 48( . )
C12N 15/ 09( . )
C12P 21/ 02( . )
 A61K 38/ 00( . )
A61P 13/ 02( . )
A61P 25/ 00( . )
C07K 14/ 475( . )
C07K 19/ 00( . )
C12N 15/ 12( . )
C12R 1/ 91( . )
(86) International application number:
PCT/US1992/004266
(87) International publication number:
WO 1992/020365 (26.11.1992 Gazette 1992/29)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30) Priority: 21.05.1991 US 19910703450
12.07.1991 US 19910729253
23.07.1991 US 19910734422
28.08.1991 US 19910751356
20.09.1991 US 19910762674
14.11.1991 US 19910791924

(71) Applicants:
  • REGENERON PHARMACEUTICALS, INC.
    Tarrytown, NY 10591-6707 (US)
  • HALLBOOK, Finn
    S-752 31 Uppsala (SE)
  • IBANEZ MOLINER, Carlos Fernando
    S-126 38 Hagersten (SE)
  • PERSSON, Hakan Bengt
    S-147 43 Tumba (SE)

(72) Inventors:
  • HALLBOOK, Finn
    S-752 31 Uppsala (SE)
  • IBANEZ MOLINER, Carlos, Fernando
    S-126 38 Hagersten (SE)
  • PERSSON, Hakan, Bengt
    S-147 43 Tumba (SE)
  • IP, Nancy
    Stamford, CT 06902 (US)
  • YANCOPOULOS, George, D.
    Briarcliff Manor, NY 10510 (US)

(74) Representative: Hirsch, Marc-Roger, et al 
Cabinet Hirsch 34 rue de Bassano
F-75008 Paris
F-75008 Paris (FR)

   


(54) THERAPEUTIC AND DIAGNOSTIC METHODS BASED ON NEUROTROPHIN-4 EXPRESSION