(19)

(11)

EP 0 588 852 A1

(12)

(43) Date of publication: 30.03.1994 Bulletin 1994/13 (21) Application number: 92911470.0 (22) Date of filing: 09.06.1992

(51) International Patent Classification (IPC):  C07H 5/ 06( . ) A61K 31/ 7008( . ) A61K 31/ 7028( . ) A61P 37/ 00( . ) C07H 13/ 06( . ) C07H 19/ 10( . ) C12P 19/ 26( . ) A61K 31/ 70( . ) A61K 31/ 7024( . ) A61P 29/ 00( . ) C07H 3/ 06( . ) C07H 15/ 04( . ) C07H 19/ 20( . ) A61K 39/ 00( . ) (86) International application number: PCT/CA1992/000244 (87) International publication number: WO 1992/022301 (23.12.1992 Gazette 1992/32)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 10.06.1991 US 19910714161 02.10.1991 US 19910771259 26.05.1992 US 19920889017 (71) Applicant: ALBERTA RESEARCH COUNCIL Edmonton Alberta T6H 5X2 (CA)	(72) Inventors: IPPOLITO, Robert Edmonton, Alberta T6L 1E7 (CA) SMITH, Richard, H. Edmonton, Alberta T6R 2A6 (CA) VENOT, Andre, P. Edmonton, Alberta T6G 0G9 (CA) KASHEM, Mohammed, A. Edmonton, Alberta T6K 1V4 (CA) (74) Representative: Nash, David Allan  Haseltine Lake & Co. Hazlitt House 28 Southampton Buildings Chancery Lane London WC2A 1AT London WC2A 1AT (GB)