(19)

(11)

EP 0 588 881 A1

(12)

(43) Date of publication: 30.03.1994 Bulletin 1994/13 (21) Application number: 92912090.0 (22) Date of filing: 08.05.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 48/ 00( . ) C07H 21/ 00( . ) A61K 31/ 7088( . ) A61P 31/ 12( . ) (86) International application number: PCT/US1992/003867 (87) International publication number: WO 1992/020697 (26.11.1992 Gazette 1992/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 10.05.1991 US 19910698568 (71) Applicant: HYBRIDON, Inc. Worcester, Massachusetts 01605 (US)	(72) Inventors: AGRAWAL, Sudhir Shrewsbury, MA 01545 (US) TEMSAMANI, Jamal Shrewsbury, MA 01545 (US) TANG, Jin-Yan Worcester, MA 06104 (US) (74) Representative: Eyles, Christopher Thomas  W.P. THOMPSON & CO. Celcon House 289-293 High Holborn London WC1V 7HU London WC1V 7HU (GB)