(19)

(11)

EP 0 588 958 A1

(12)

(43) Date of publication: 30.03.1994 Bulletin 1994/13 (21) Application number: 92914168.0 (22) Date of filing: 05.05.1992

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) G01N 33/ 558( . ) G01N 33/ 58( . ) G01N 33/ 543( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1992/003680 (87) International publication number: WO 1992/022797 (23.12.1992 Gazette 1992/32)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 13.06.1991 US 19910715407 14.06.1991 US 19910715119 (71) Applicant: PACIFIC BIOTECH INC. San Diego California 92121 (US)	(72) Inventors: TZENG, Sinfu San Francisco, CA 94132 (US) WANG, Dou-Mei Encinitas, CA 92024 (US) (74) Representative: Maury, Richard Philip, et al  Sommerville & Rushton 11 Holywell Hill St. Albans Herts. AL1 1EZ St. Albans Herts. AL1 1EZ (GB)