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(11)

EP 0 589 886 A1

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(43) Date of publication: 06.04.1994 Bulletin 1994/14 (21) Application number: 92905563.0 (22) Date of filing: 02.03.1992

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61P 31/ 04( . ) A61K 31/ 397( . ) C07D 477/ 00( . ) (86) International application number: PCT/EP1992/000459 (87) International publication number: WO 1992/015587 (17.09.1992 Gazette 1992/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 07.03.1991 GB 19910004832 (71) Applicant: GLAXO S.p.A. I-37100 Verona (IT)	(72) Inventors: BIONDI, Stefano I-37100 Verona (IT) ANDREOTTI, Daniele I-37100 Verona (IT) ROSSI, Tino I-37100 Verona (IT) CARLESSO, Robert I-37100 Verona (IT) TARZIA, Giorgio I-37100 Verona (IT) PERBONI, Alcide I-37100 Verona (IT) (74) Representative: Brewer, Christopher Laurence, et al  Glaxo Wellcome plc Glaxo House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)