(19)
(11) EP 0 590 027 A1

(12)

(43) Date of publication:
06.04.1994 Bulletin 1994/14

(21) Application number: 92913432.0

(22) Date of filing: 02.06.1992
(51) International Patent Classification (IPC): 
A61K 39/ 04( . )
A61P 31/ 04( . )
C07K 14/ 35( . )
C12N 15/ 09( . )
A61K 39/ 00( . )
A61P 31/ 00( . )
A61P 31/ 06( . )
C12N 1/ 21( . )
C12N 15/ 74( . )
C12R 1/ 32( . )
(86) International application number:
PCT/US1992/004706
(87) International publication number:
WO 1992/022326 (23.12.1992 Gazette 1992/32)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30) Priority: 13.06.1991 US 19910714656
12.12.1991 US 19910806706

(60) Divisional application:
99110251.8 / 0972839

(71) Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
Bronx New York 10461 (US)

(72) Inventors:
  • JACOBS, William, R.
    City Island, NY 10464 (US)
  • BLOOM, Barry
    Hastings-on-Hudson, NY 10706 (US)
  • KALPANA, Ganjam, V.
    Bronx, NY 10461 (US)
  • CIRILLO, Jeffrey, D.
    Bronx, NY 10461 (US)

(74) Representative: LOUIS, PÖHLAU, LOHRENTZ & SEGETH 
Postfach 3055
D-90014 Nürnberg
D-90014 Nürnberg (DE)

   


(54) INSERTIONAL MUTATIONS IN MYCOBACTERIA