(19)
(11)
EP 0 590 051 A1
(12)
(43)
Date of publication:
06.04.1994
Bulletin 1994/14
(21)
Application number:
92914138.0
(22)
Date of filing:
11.06.1992
(51)
International Patent Classification (IPC):
A61K
38/
00
( . )
A61K
39/
395
( . )
A61P
29/
00
( . )
C07K
14/
00
( . )
C07K
16/
00
( . )
C07K
16/
28
( . )
C12N
5/
10
( . )
C12N
15/
09
( . )
C12P
21/
08
( . )
G01N
33/
53
( . )
G01N
33/
577
( . )
A61K
39/
00
( . )
A61K
48/
00
( . )
A61P
37/
00
( . )
C07K
14/
705
( . )
C07K
16/
18
( . )
C07K
19/
00
( . )
C12N
15/
00
( . )
C12P
21/
02
( . )
C12Q
1/
68
( . )
G01N
33/
569
( . )
(86)
International application number:
PCT/US1992/004896
(87)
International publication number:
WO 1992/022323
(
23.12.1992
Gazette 1992/32)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
(30)
Priority:
11.06.1991
US 19910712879
(71)
Applicant:
CENTER FOR BLOOD RESEARCH, INC.
Boston, MA 02115 (US)
(72)
Inventors:
DeFOUGEROLLES, Antonin, R.
Cambridge, MA 02138 (US)
SPRINGER, Timothy, A.
Chestnut Hill, MA 02167 (US)
(74)
Representative:
Roberts, Alison Christine
Kilburn & Strode, 30 John Street
London WC1N 2DD
London WC1N 2DD (GB)
(54)
INTERCELLULAR ADHESION MOLECULE-3 AND ITS BINDING LIGANDS