(19)

(11)

EP 0 590 057 A1

(12)

(43) Date of publication: 06.04.1994 Bulletin 1994/14 (21) Application number: 92914211.0 (22) Date of filing: 19.06.1992

(51) International Patent Classification (IPC):  C07K 14/ 16( . ) C40B 40/ 02( . ) G01N 33/ 569( . ) C12N 15/ 10( . ) G01N 33/ 543( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1992/004972 (87) International publication number: WO 1992/022579 (23.12.1992 Gazette 1992/32)

(84) Designated Contracting States: DE FR GB IT NL (30) Priority: 19.06.1991 US 19910717400 12.07.1991 US 19910729064 (71) Applicant: IMMULOGIC PHARMACEUTICAL CORPORATION Waltham, Massachusetts 02154 (US)	(72) Inventors: GEFTER, Malcolm, L. Weston, MA 02193 (US) MELMON, Kenneth, L. Woodside, CA 94062 (US) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Bakers Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)