(19)

(11)

EP 0 590 083 A1

(12)

(43) Date of publication: 06.04.1994 Bulletin 1994/14 (21) Application number: 92914946.0 (22) Date of filing: 12.06.1992

(51) International Patent Classification (IPC):  C07D 493/ 04( . ) C12P 17/ 18( . ) C12P 1/ 06( . ) (86) International application number: PCT/US1992/005108 (87) International publication number: WO 1992/022660 (23.12.1992 Gazette 1992/32)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 14.06.1991 US 19910715518 (71) Applicant: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)	(72) Inventors: TREIBER, Laszlo, R. Gillette, NJ 07933 (US) HUANG, Leeyuan Watchung, NJ 07060 (US) CHEN, Shieh-Shung, Tom Morganville, NJ 07751 (US) ARISON, Byron, H. Watchung, NJ 07060 (US) (74) Representative: Cole, William Gwyn  European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)