(19)

(11)

EP 0 591 284 A1

(12)

(43) Date of publication: 13.04.1994 Bulletin 1994/15 (21) Application number: 92912498.0 (22) Date of filing: 24.06.1992

(51) International Patent Classification (IPC):  A61K 9/ 16( . ) A61K 47/ 48( . ) A61K 9/ 51( . ) (86) International application number: PCT/EP1992/001425 (87) International publication number: WO 1993/000076 (07.01.1993 Gazette 1993/02)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 24.06.1991 DE 19914120760 (71) Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY St. Paul, Minnesota 55133-3427 (US)	(72) Inventors: ZERBE, Horst D-4282 Velen (DE) KREUTER, Jörg D-6380 Bad Homburg (DE) ZIMMER, Annette D-6000 Frankfurt (DE) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)