(19)

(11)

EP 0 591 320 A1

(12)

(43) Date of publication: 13.04.1994 Bulletin 1994/15 (21) Application number: 92913077.0 (22) Date of filing: 03.06.1992

(51) International Patent Classification (IPC):  A61K 35/ 14( . ) A61K 39/ 395( . ) C07K 1/ 00( . ) C07K 14/ 00( . ) C07K 14/ 52( . ) C07K 16/ 18( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) G01N 33/ 577( . ) A61K 38/ 00( . ) A61P 37/ 06( . ) C07K 1/ 22( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) C07K 16/ 24( . ) C12N 15/ 02( . ) G01N 33/ 53( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1992/004614 (87) International publication number: WO 1992/021240 (10.12.1992 Gazette 1992/31)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 03.06.1991 US 19910709375 (71) Applicant: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY La Jolla, CA 92037 (US)	(72) Inventor: KIMISHIGE, Ishizaka La Jolla, CA 92037 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)