(19)

(11)

EP 0 591 503 A1

(12)

(43) Date of publication: 13.04.1994 Bulletin 1994/15 (21) Application number: 93909068.0 (22) Date of filing: 20.04.1993

(51) International Patent Classification (IPC):  C07C 227/ 18( . ) C07D 263/ 22( . ) C07C 229/ 34( . ) (86) International application number: PCT/GB1993/000821 (87) International publication number: WO 1993/022277 (11.11.1993 Gazette 1993/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.04.1992 GB 19920009076 (71) Applicant: ZENECA LIMITED London W1Y 6LN (GB)	(72) Inventors: HOLLOWAY, Brian, Roy 64 Bailey Crescent Congleton Cheshire CW12 2EW (GB) HOWE, Ralph Little Beck Upton Cheshire SK10 3HL (GB) RAO, Balbir, Singh Cheshire CW4 7HW (GB) (74) Representative: Denerley, Paul Millington, Dr., et al  ICI Group Patents Services Dept. PO Box 6 Shire Park Bessemer Road Welwyn Garden City Herts, AL7 1HD Welwyn Garden City Herts, AL7 1HD (GB)