(19)
(11) EP 0 591 697 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
14.11.2001 Bulletin 2001/46

(45) Mention of the grant of the patent:
13.06.2001 Bulletin 2001/24

(21) Application number: 93114519.7

(22) Date of filing: 09.09.1993
(51) International Patent Classification (IPC)7: C12N 15/12, C12P 21/08, A61K 38/17, C12Q 1/68, C12N 5/10, C12N 1/21, C07K 14/00

(54)

Cloning and characterization of the growth hormone releasing hormone receptor

Klonierung und Charakterisierung des GHRH-Rezeptors

Clonage et caractérisation des récepteurs de la GHRH

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

(30) Priority: 15.09.1992 US 946232
18.09.1992 US 947672

(43) Date of publication of application:
13.04.1994 Bulletin 1994/15

(73) Proprietors:
  • The University of Virginia Patent Foundation
    Charlottesville, Virginia 22906-9011 (US)
  • American Cyanamid Company
    Wayne, New Jersey 07470 (US)

(72) Inventors:
  • Thorner, Michael Oliver
    North Garden, Virginia 22959 (US)
  • Gaylinn, Bruce David
    Trevilians, Virginia 23093 (US)
  • Zysk, John Ronald
    French Town, New Jersey 08825 (US)
  • Lynch, Kevin R.
    Charlottesville, Virginia 22903 (US)
  • Harrison, Jeffrey K.
    Gainesville, Florida 32607 (US)

(74) Representative: Wächtershäuser, Günter, Prof. Dr. 
Wächtershäuser & Hartz, Patentanwälte, Tal 29
80331 München
80331 München (DE)


(56) References cited: : 
EP-A- 0 506 032
WO-A-92/10565
 EP-A- 0 576 988
   
  • JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol.66, no.6, 1988, PHILADELPHIA PA, USA pages 1265 - 1271 S. IKUYAMA ET AL. 'Characterization of growth hormone-releasing hormone receptors in pituitary adenomas from patients with acromegaly.'
  • THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol.261, no.36, 25 December 1986, BALTIMORE MD, USA pages 16781 - 16784 J. ZYSK ET AL. 'Cross-linking of a growth hormone releasing factor-binding protein in anterior pituitary cells.'
  • MOLECULAR ENDOCRINOLOGY, vol.7, no.1, January 1993, BALTIMORE MD, USA pages 77 - 84 B. GAYLINN ET AL. 'Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.'
  • MOLECULAR ENDOCRINOLOGY, vol.6, no.10, October 1992, BALTIMORE MD, USA pages 1734 - 1744 K. MAYO 'Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.'
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).