(19)

(11)

EP 0 593 580 A1

(12)

(43) Date of publication: 27.04.1994 Bulletin 1994/17 (21) Application number: 92914421.0 (22) Date of filing: 19.06.1992

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) C12Q 1/ 68( . ) C12N 15/ 10( . ) (86) International application number: PCT/US1992/005222 (87) International publication number: WO 1993/000353 (07.01.1993 Gazette 1993/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 20.06.1991 US 19910716831 12.02.1992 US 19920837195 (71) Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Washington, DC 20000 (US)	(72) Inventors: VENTER, J., Craig Silver Spring, MD 20906 (US) ADAMS, Mark, D. Germantown, MD 20874 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)