(19)

(11)

EP 0 593 631 A1

(12)

(43) Date of publication: 27.04.1994 Bulletin 1994/17 (21) Application number: 92915315.0 (22) Date of filing: 26.06.1992

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 10( . ) C12N 15/ 85( . ) C12N 9/ 64( . ) C12N 15/ 12( . ) C12N 15/ 90( . ) (86) International application number: PCT/US1992/005409 (87) International publication number: WO 1993/001292 (21.01.1993 Gazette 1993/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 01.07.1991 US 19910724204 (71) Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY Bronx New York 10461 (US)	(72) Inventor: KUCHERLAPATI, Raju Darien, CT 06820 (US) (74) Representative: O'Brien, Caroline Jane, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)