(19)

(11)

EP 0 593 663 A1

(12)

(43) Date of publication: 27.04.1994 Bulletin 1994/17 (21) Application number: 92915861.0 (22) Date of filing: 23.04.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 715( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 475( . ) C12N 15/ 09( . ) G01N 33/ 50( . ) A61K 31/ 55( . ) A61K 33/ 24( . ) A61K 38/ 22( . ) A61P 35/ 00( . ) C12N 5/ 10( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1992/003392 (87) International publication number: WO 1993/000909 (21.01.1993 Gazette 1993/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 03.07.1991 US 19910728784 20.09.1991 US 19910762675 (71) Applicant: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US)	(72) Inventors: SQUINTO, Stephen, P. Irvington, NY 10533 (US) NYE, Steven, H. New York, NY 10128 (US) YANCOPOULOS, George, D. Briarcliffe Manor, NY 10510 (US) (74) Representative: Hirsch, Marc-Roger, et al  Cabinet Hirsch 34 rue de Bassano F-75008 Paris F-75008 Paris (FR)