(19)

(11)

EP 0 593 761 A1

(12)

(43) Date of publication: 27.04.1994 Bulletin 1994/17 (21) Application number: 91910169.0 (22) Date of filing: 31.05.1991

(51) International Patent Classification (IPC):  A61K 31/ 38( . ) A61P 25/ 04( . ) A61P 37/ 00( . ) C07D 333/ 22( . ) C07D 333/ 28( . ) C07D 333/ 32( . ) C07D 333/ 36( . ) C07D 409/ 04( . ) A61K 31/ 381( . ) A61P 29/ 00( . ) C07D 333/ 12( . ) C07D 333/ 24( . ) C07D 333/ 30( . ) C07D 333/ 34( . ) C07D 333/ 38( . ) C07D 409/ 12( . ) (86) International application number: PCT/JP1991/000744 (87) International publication number: WO 1991/019708 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 11.06.1990 GB 19900012936 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP)	(72) Inventors: MATSUO, Masaaki Toyonaka-shi Osaka 560 (JP) TSUJI, Kiyoshi Kishiwada-shi Osaka 596 (JP) KONISHI, Nobukiyo Kyoto 617 (JP) NAKAMURA, Katsuya Takatsuki-shi Osaka 569 (JP) (74) Representative: Türk, Gille, Hrabal, Leifert  Brucknerstrasse 20 D-40593 Düsseldorf D-40593 Düsseldorf (DE)