(19)

(11)

EP 0 594 600 A1

(12)

(43) Date of publication: 04.05.1994 Bulletin 1994/18 (21) Application number: 91905827.0 (22) Date of filing: 13.03.1991

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61P 37/ 06( . ) C07H 19/ 01( . ) A61K 31/ 435( . ) C07D 498/ 18( . ) (86) International application number: PCT/GB1991/000393 (87) International publication number: WO 1991/013889 (19.09.1991 Gazette 1991/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 13.03.1990 GB 19900005672 17.04.1990 GB 19900008556 17.04.1990 GB 19900008507 27.04.1990 GB 19900009480 09.08.1990 GB 19900017447 25.10.1990 GB 19900023242 (71) Applicant: FISONS plc Ipswich Suffolk IP1 1QH (GB)	(72) Inventors: DONALD, David Keith Leicestershire LE6 5FE (GB) FURBER, Mark Kegworth, Derby DE7 2EN (GB) COOPER, Martin Edward Loughborough, Leicestershire LE11 0FE (GB) (74) Representative: Wright, Robert Gordon McRae  FISONS plc 12 Derby Road Loughborough Leicestershire LE11 0BB Loughborough Leicestershire LE11 0BB (GB)