(19)

(11)

EP 0 594 749 A1

(12)

(43) Date of publication: 04.05.1994 Bulletin 1994/18 (21) Application number: 92915801.0 (22) Date of filing: 15.07.1992

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 47/ 48( . ) A61P 43/ 00( . ) C07K 7/ 08( . ) C07K 14/ 52( . ) C07K 14/ 76( . ) C12N 1/ 21( . ) C12N 15/ 19( . ) C12R 1/ 19( . ) A61K 39/ 395( . ) A61K 49/ 00( . ) C07K 7/ 06( . ) C07K 14/ 00( . ) C07K 14/ 705( . ) C07K 16/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1992/005903 (87) International publication number: WO 1993/002192 (04.02.1993 Gazette 1993/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 15.07.1991 US 19910731222 (71) Applicant: REPLIGEN CORPORATION Cambridge, MA 02139 (US)	(72) Inventor: MAIONE, Theodore, E. Wakefield, MA 01880 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)