(19)

(11)

EP 0 595 863 A1

(12)

(43) Date of publication: 11.05.1994 Bulletin 1994/19 (21) Application number: 92915026.0 (22) Date of filing: 09.07.1992

(51) International Patent Classification (IPC):  A61L 27/ 00( . ) A61L 27/ 54( . ) A61K 38/ 46( . ) C12N 11/ 02( . ) (86) International application number: PCT/GB1992/001247 (87) International publication number: WO 1993/000935 (21.01.1993 Gazette 1993/03)

(84) Designated Contracting States: CH DE FR GB LI NL SE (30) Priority: 11.07.1991 EP 19910306305 (71) Applicant: BRITISH TECHNOLOGY GROUP LTD London SE1 6BU (GB)	(72) Inventors: BEERSTEN, Wouter NL-2082 BK Santpoort (NL) VAN DEN BOS, Theo NL-3704 WE Zeist (NL) (74) Representative: Percy, Richard Keith  Patents Department British Technology Group Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)