(19)

(11)

EP 0 597 830 A1

(12)

(43) Date of publication: 25.05.1994 Bulletin 1994/21 (21) Application number: 90911163.0 (22) Date of filing: 03.07.1990

(51) International Patent Classification (IPC):  A61K( . ) A61K 31/ 16( . ) C07C 237/ 10( . ) C07C 279/ 12( . ) A61K 31/ 13( . ) C07C 211/ 14( . ) C07C 239/ 16( . ) C07C 279/ 14( . ) (86) International application number: PCT/US1990/003771 (87) International publication number: WO 1991/000853 (24.01.1991 Gazette 1991/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 05.07.1989 US 19890375776 26.10.1989 US 19890427333 (71) Applicant: NEW YORK UNIVERSITY NYU MEDICAL CENTER New York, NY 10016 (US)	(72) Inventors: CHERKSEY, Bruce, D. Hoboken, NJ 07030 (US) LLINAS, Rodolfo, R. New York, NY 10021 (US) SUGIMORI, Mutsuyuki New York, NY 10010 (US) (74) Representative: Vetter, Ewald Otto, Dipl.-Ing.  Patentanwaltsbüro Allgeier & Vetter Postfach 10 26 05 D-86016 Augsburg D-86016 Augsburg (DE)