(19)

(11)

EP 0 598 037 A1

(12)

(43) Date of publication: 25.05.1994 Bulletin 1994/21 (21) Application number: 92917825.0 (22) Date of filing: 04.08.1992

(51) International Patent Classification (IPC):  A61K 38/ 44( . ) A61P 9/ 00( . ) A61K 47/ 48( . ) C12N 9/ 96( . ) (86) International application number: PCT/US1992/006433 (87) International publication number: WO 1993/002701 (18.02.1993 Gazette 1993/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 05.08.1991 US 19910740255 (71) Applicant: STERLING WINTHROP INC. New York, NY 10016 (US)	(72) Inventors: NA, George, C. Fort Washington, PA 19034 (US) RAJAGOPALAN, Natarajan Phoenixville, PA 19460 (US) YUAN, Barbara, O-Ching Villanova, PA 19085 (US) REVELLO, Kim, Marie Essington, PA 19029 (US) (74) Representative: Haile, Helen Cynthia, et al  Kodak Limited Patent Department Headstone Drive Harrow, Middlesex HA1 4TY Harrow, Middlesex HA1 4TY (GB)